Posted by admin on Sep 30, 2019 in |
Aim: The aim of the study was to evaluate the dental status of diabetic patients. Objective: To evaluate the oral change viz., periodontal status, the status of alveolar bone, gingival status in type-1 and type-2 diabetic patients. Background: The term diabetes mellitus describes a group of disorders characterized by an elevated level of glucose in the blood and abnormalities of carbohydrate, fat and protein metabolism. Oral disorders like periodontitis, tooth loss, gingivitis, salivary dysfunction, dental caries, oral mucosal diseases, dental caries and oral infections like candidiasis, taste and other neurosensory orders are associated with diabetes mellitus. Reason: Diabetes mellitus is an important health care problem. The oral health care providers can have a significant and positive effect on the oral and general health of patients with diabetes...
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Posted by admin on Aug 31, 2019 in |
Green synthesis of silver nanoparticles from naturally occurring biomaterials provides an alternative, eco-friendly and cost-effective means of obtaining nanoparticles. It is an important thrust area for all scientists and has gained importance because it prevents the environment from pollution. Multi-drug resistance is a growing problem in the treatment of infectious diseases and the widespread use of broad-spectrum antibiotics has produced antibiotic resistance for many human bacterial pathogens. Advancement in nanotechnology has opened a new field in nanomedicine, allowing the synthesis of nanoparticles and evaluation of their synergistic effect with pre-existing antibiotics that can be assembled into a complex structure. Novel studies and technologies are developed to understanding the mechanisms of disease for the design of new drugs, but unfortunately, infectious diseases continue to be a major health problem worldwide. Since ancient times, silver was known for its anti-bacterial effects and for centuries it has been used for prevention and control of disparate infections. Now-a-days vancomycin resistance in gram-positive Cocci is a growing global health problem. In the early 1950s,...
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Posted by admin on Aug 31, 2019 in |
The aim of the present study was comprehensively establishing the utility of PAMAM dendrimers in solubility enhancement of Flurbiprofen. It can be concluded that PAMAM dendrimers in the solubility of Flurbiprofen but also helped to localize the drug at the site of action and the drug can provide better therapeutic efficacy with lower dose by reducing its adverse effect. From the solubilization study, it was observed that the increase in solubility was due to the dendrimeric complexation or encapsulation. From this paper, it can also be concluded that formulation containing more amount of dendrimer concentration provides a higher flux than formulation containing a lower amount of dendrimer. This may be due to an increased thermodynamic activity of the drug in dendrimic formulation at a lower concentration of...
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Posted by admin on Jun 30, 2019 in |
Bryophyllum pinnatum (Lam.) Kurz. widely used in traditional as well as folk medicinal systems are locally known as Panphuti. Traditionally, it is used for the treatment of kidney stones, urinary tract infection, burns, and diarrhea. In the present study, pharmacognostic studies of root, stem, and leaf of B. pinnatum (Lam.) Kurz. For standardization of plant material morphological and anatomical characterization was carried out. Intra-stelar and extra-stelar secondary growth with wood and periderm formation along with deposition of starch grains were observed in the pith region of the root and cortical region of the stem. Calcium oxalate crystals were also present in the cortical region of the stem. Leaf lamina showed spongy parenchyma in mesophyll region and anisocytic type of stomata. Anthocyanin pigment was present below epidermal cells in the petiole. He results of the study could be useful in setting some diagnostic indices for the identification and preparation of monograph of the...
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Posted by admin on May 31, 2019 in |
The purpose of the current study was to formulate nanosized bromocriptine loaded mucoadhesive bio-flexy films using biopolymer from Zea mays for improved bioavailability and therapeutic efficacy via oro-trans labio mucosal route. Bromocriptine was nanosized by a novel method using 1,2,3-propanetriol as nanosizant. The biopolymer was isolated from Zea mays by treating the aqueous extract with an optimized quantity of non-aqueous solvent. Ten nanosized drug loaded films in different ratios (1:1, 1:2,1:3, 1:4 and 1:5) of biopolymer from Zea mays and Guar gum were prepared by “Solvent Casting Technique.” Biopolymer from Zea mays and Guar gum was used as film former, 1,2,3-Propanetriol and D-glucose as flexicizer. All the films were evaluated using thickness, surface pH, folding endurance, weight and content uniformity, mucoadhesive, in-vitro drug release profile, etc. The isolated biopolymer was off-white in color, biodegradable and biocompatible. All films were thin, smooth, transparent to translucent in appearance and flexible in nature. All formulations adhered to the mucosal surface for more than 24 h. The amount of film former influenced the...
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