Posted by admin on Mar 31, 2019 in |
In marine habitats, a wide diversity of microorganisms such as bacteria, archaea, fungi, and microalgae will exist. Many investigations were reported in the literature on the diversity of marine bacteria and archaea, including their role, usefulness in various domains. It is found from the literature that less work has been reported in the literature related to the role and significance of microbes. Several orders of magnitude between the number of cells will be seen in seawater samples by direct observation and the number of colonies that can grow on agar plates. To prepare subculture, colonies were inoculated in nutrient agar and broth. Bacterial communities are composed of known species which are capable of forming colonies on agar plates but do so with low efficiency. Biochemical investigations were carried out in unknown bacterial samples collected from seawater to know the characteristic of...
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Posted by admin on Dec 31, 2018 in |
Purpose: The main objective of the present research investigation is to formulate the sustained release formulation of Rosuvastatin. Rosuvastatin, an antihyperlipidemic agent, belong BCS class-II agent. Methods: The SR tablets of Rosuvastatin were prepared to employ different concentrations of HPMCK4M and SCMC in different combinations by direct compression using 32 factorial designs. The concentration of polymers, HPMCK4M, and SCMC required to achieve the desired drug release was selected as independent variables, X1, and X2 respectively whereas, time required for 10% of drug dissolution (t10%), 50% (t50%), 75% (t75%) and 90% (t90%) were selected as dependent variables. Results and Discussion: nine formulations were designed and are evaluated for hardness, friability, thickness, % drug content, in-vitro drug release. From the results, it was concluded that all the formulation were found to be within the Pharmacopoeial limits and the in-vitro dissolution profiles of all formulations were fitted into different kinetic models, the statistical parameters like intercept, slope & regression coefficient were calculated. Polynomial equations were developed for dependent variables. The validity of...
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Posted by admin on Oct 30, 2018 in |
Transdermal drug delivery has been accepted as a potential non-invasive route of drug administration, with advantages of prolonged therapeutic action, less side effect, easy use, and improved patient compliance. Glimepiride is an anti-diabetic drug with a shorter half-life of ~5 h, low bioavailability, and extensive first-pass metabolism due to these limitations required to maintain the therapeutic level it has chosen as a transdermal drug delivery system. To formulate and evaluate the transdermal drug delivery system of Glimepiride using polymers such as tristearin, soya lecithin, and Eudragit RS100 by solvent casting technique. Formulation of transdermal patches of glimepiride and optimization of SLN transdermal patches. Central composite design (CCD) was applied by using design-expert to optimize the composition of tristearin and soya lecithin for transdermal drug delivery. Prepared drug loaded SLNs were evaluated for particle size analysis, DSC, Drug entrapment efficiency, SEM, and in-vitro release studies. The present study of formulation and preparation of transdermal patches of Glimipride to provide better efficiency of drug another dosage...
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Posted by admin on Aug 31, 2018 in |
Present study aimed to develop a microemulsion system for topical application of Amoxicillin to provide various advantages over conventional dosage forms. Amoxicillin is broad-spectrum semisynthetic antibiotic similar to ampicillin except that its resistance to gastric acid permits higher serum levels with oral administration. Amoxicillin is commonly prescribed with clavulanic acid (a beta-lactamase inhibitor) as it is susceptible to beta-lactamase degradation. Clinical studies show that it is highly effective for topical treatment of skin infections. The microemulsion was prepared using oleic acid as an oil phase, tween 20 as surfactant and propylene glycol as co-surfactant. The drug was evaluated for their micropolitical properties like the angle of repose, bulk density; tapped density, Carr’s index, and Hausner’s ratio were studied. In-vitro characterization of the microemulsion of amoxicillin was done through measurement of pH, conductivity, viscosity, drug...
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Posted by admin on Aug 31, 2018 in |
Aim: To study the status of restoration and prevalence of caries in patients witha removable partial denture. Materials and Method: Case sheets of 100 RPD (removable partial denture) patients were collected, and the prevalence of caries and restorative status were assessed from it. Results: From the 100 subjects, 36% of the RPD patients had caries. Based on the restorative status, 12 subjects did not undergo any restorative treatment, while the rest had undergone restoration. Conclusion: The prevalence of caries in patients with RPD was found to be higher than that of patients with a fixed partial denture (FPD). Therefore, alterations can be made in the design of RPD such that it will reduce the incidence of caries in RPD wearers. Awareness of oral hygiene should be given to patients with...
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