Posted by admin on Oct 16, 2017 in |
Contaminated injection equipment have a pivotal role in the spread of HCV infection. IV drug users are one of the populations with a high risk of HCV infection. Objectives: our goal was to evaluate the role of a hazardous action (intravenous injection with contaminated equipment) in threat of public health. In this study, we collected data on 37 psychiatric patients with a history of IV drug abuse and addiction with HCV and compared to psychiatric patients with a history of IV drug abuse without HCV. Here was measured biochemical and hematological parameters and analyzed by SPSS. We found levels of AST and ALT significantly increased, but ALP and albumin none significantly decreased in patients (p≤0.05). Moreover, PT, aPTT, and ESR levels in patients were slightly higher than the control group. Also, a significant correlation between AST and ALT to serum creatinine in patients may indicate a relationship between kidney problems followed by hepatic damage. The mean value of FBS, Tg, and cholesterol levels was nearly similar in both groups....
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Posted by admin on Oct 16, 2017 in |
Preeclampsia is a pregnancy-related disorder and considered as one of the major reasons for infants and mothers death in developed nations. HELLP disorder is a problem related to child birth that usually happens in women with intense preeclampsia and associated with different features, including hemolysis, elevated liver enzymes, and low platelet count. Due to normal hepatic markers during pregnancy, our purpose is to examine these factors in pregnant women and their association with disorders such as preeclampsia and HELLP syndrome. This case-control study included 99 Iranian pregnant women that divided two groups including preeclamptic and normotensive pregnant women. Samples were collected from Ahvaz city. We measured liver enzymes activity (ALT, AST, and ALP), total bilirubin and direct bilirubin and blood platelets by calorimetry methods in both groups. The results showed that there was no significant difference in the platelet level in both groups. However, we found a significant difference in the serum level of ALT, AST, ALP and total bilirubin between two groups (p<0.05), while the result related to direct...
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Posted by admin on Jul 12, 2017 in |
Nanoparticles represent a promising drug delivery system of controlled and targeted release. The current research work was to explore a novelistic route for targeting to the brain through the ear by formulating nanosuspension using Escitalopram as a model drug permitting better control over depression. Depression is the second most prevailing disease after cardiovascular diseases. The delivery has overcome the dose dumping problem in case of the oral system. In this research work, significant effort was made to explore the novelistic platform for the ear to the brain. Bio-nano suspensions were prepared by using a biopolymer which was isolated from berries of Piper nigrum. Eight formulations were prepared of different ratios i.e. 1:0.5, 1:1, 1:2, 1:3, 1:4, 1:5, 1:7, 1:10,. The formulations were subjected to various evaluations, including pH, % transmittance, Content uniformity, ex-vivo, stability, release for over 36 h. Different formulations of Escitalopram out of which F1 (1:0.5) was found to be the best formulation having an r2 value of 0.9905 t 80: 22 h and best-fit model was...
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Posted by admin on Jul 12, 2017 in |
A stability-indicating High-Performance Thin-Layer Chromatographic method (HPTLC) was developed and validated as per the International Conference on Harmonization (ICH) guidelines for determination of carvedilol (CRL) both in bulk drug and solid lipid nanoparticles (SLNs). The solvent system comprised of toluene–chloroform-methanol-acetic acid (2.0:2.0:1.0:0.04, v/v/v), gave compact spot of CRL at Rf 0.56 ± 0.05. The spectrodensitometric analysis was performed at 242 nm. The linear graph upon regression analysis showed r2 = 0.998 concerning peak area at the concentration range of 50–1000 ng spot−1. The limit of detection and quantification was found to be 7.9 and 24.2 ng spot-1, respectively. The drug was subjected to stress conditions like acid and alkali hydrolysis, oxidation, photodegradation, dry as well as wet heat treatment and evaluated for stability and degradation product. The acidic and alkaline degradation kinetics was also studied using developed HPTLC method. SLNs were developed using hot melt technique and subjected stability testing along with the commercial...
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Posted by admin on Jul 12, 2017 in |
Background: In the emergency department, doctors face urgent and severe cases that need to be treated quickly with high quality. Therefore, clinicians often face challenges in selecting, initiating and individualizing appropriate drug therapy for patients admitted in the emergency medicine ward. Objective: To assess the prescribing patterns of drugs and to determine the rationality of prescriptions by using World Health Organization prescribing indicators. Materials and Methods: A prospective cross sectional study was carried out in emergency department for six months. About 520 case sheets were reviewed. Data were collected using structural data entry form and analyzed. Descriptive statistics were used to describe the data. Results: The data was collected prospectively and analyzed using WHO prescribing indicators. The average number of drugs prescribed was 6.40 per prescription. The drugs prescribed by generic name accounts for 20.9% and those prescribed from EDL include 83.88%. At least one antibiotic was prescribed for patients which is high (57.31%). Most of drugs were administered through injection for about 49.24%.Patients were mainly admitted for nausea...
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