Posted by admin on Aug 19, 2015 in |
Mouth dissolving tablet disintegrates within a minute without drinking water. The purpose of present work was to develop a patient-friendly tablet for antihypertensive treatment using Benazepril HCl was taste masked by complexing with indion 204 and formulate as mouth dissolving tablet (MDT). The formulated drug-resin complex was characterized by IR, DSC, etc. Overall nine mouth dissolving formulations were prepared by direct compression method using three different superdisintegrants viz. croscarmellose sodium, sodium starch glycolate, and crospovidone. The tablets disintegrated in-vitro within 20 s, and the complex drug was released from tablet within 3 min. Formulation F1 to F3 were prepared by direct compression method using sodium starch glycolate as superdisintegrants was found to release the drug in the range of 88.20 to 91.98%. Similarly, formulation F4 to F6, which were prepared by using crospovidone as superdisintegrants showed maximum percent drug release, i.e. 88.27 to 92.68%. Further, F7 to F9 were prepared by using croscarmellose sodium as superdisintegrants and showed percent drug release between 87.72 to 89.18% range. Studies indicated that...
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Posted by admin on Aug 19, 2015 in |
A solid dispersion is the dispersion of one or more active ingredients in an inert carrier or matrix at solid state prepared by melting, solvent, or melting-solvent Method. The poor solubility of drug substances in water and their low dissolution rate in the aqueous gastro-intestinal fluids often lead to insufficient bioavailability. If the dissolution rate of the active ingredient in the gastrointestinal liquid is the rate-limiting factor for the absorption of the drug, the objective of the formulation will have to be an increase in the dissolution rate. From many years, variety of solubility techniques have been used & studied for increasing solubility of poorly soluble drugs. Around 40% of chemical entities discovered by pharmaceutical industry are poorly soluble in nature. Solid dispersion is one of these methods, which was most widely and successfully applied to improve the solubility, dissolution rate & bioavailability of the poorly soluble drugs. This article reviews historical background of solid dispersion technology, limitations, classification, and various preparation techniques with its advantages and disadvantages. This...
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Posted by admin on Aug 19, 2015 in |
The marine world is largely unexplored that harbors most of the biodiversity. In recent years, marine natural products have yielded a considerable number of drug candidates. Marine microorganisms, whose genetic and biochemical diversity became a rich source of novel chemical entities for the discovery of more effective drugs. Marine microbes especially marine sponges are playing a unique contribution for human health and well- being. In addition to the primary metabolites (amino acids, nucleotides, and vitamins), they also contribute many secondary metabolites, which constitute 50% of the pharmaceuticals. Drugs derived from the marine natural products are being developed for treating cancers, immune suppressive disorders, and resistant microbial species. The need to augment production of these marine compounds to prepare various drugs through tissue culture and mariculture and their uses in human population has been stressed on this...
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Posted by admin on Jul 21, 2015 in |
The supply of non-renewable energy sources from fossil fuel is depleting day by day, and it has become one of the greatest challenges to find alternative sources. Bioethanol as alternative biofuels has stimulated the worldwide interest. The use of bioethanol as fuel will minimize the amounts of fossil-derived carbon dioxide (CO2) to the Earth’s atmosphere. Yeast is the most acceptable of all organisms for ethanol production because of its diverse substrate specificity and ease of production of ethanol. Temperature is one of the most important environmental factors affecting microbial activity and production cost. The main objective of this research work was to isolation, characterization, and process optimization of ethanol-producing thermotolerant yeast strains. In total, 5 yeast isolates have been characterized based on morphological and physicochemical characters. Most of the strains were thermotolerant, ethanol tolerant, pH tolerant, as well as osmotolerant. All the strains were formed pseudo mycelium under stress condition. They were resistant to chloramphenicol, but growth was inhibited in the presence of 1% acetic Acid. The strains C...
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Posted by admin on Jul 20, 2015 in |
Objective: To explore the effects of glucose concentration on the growth of Wharton’s jelly mesenchymal stem cells from umbilical cords of gestational diabetic mothers (DWJMSCs) and normal mothers (NWJMSCs). Methods: NWJMSCs and DWJMSCs were treated at passage 3 with low (5.5mM) or high glucose. Cells’ growth was evaluated by methyl thiazolyl tetrazolium uptake and cytotoxicity by LDH release. Status of oxidative stress was estimated by the release of stress enzymes, i.e., glutathione s transferase (GSH) and catalase. Results: The results of cells’ growth assays indicated a significant increase in proliferation in DWJMSCs when treated with high glucose as compared to low glucose while the opposite was found in NWJMSCs. Conversely, cytotoxicity was lower in DWJMSCs treated with 25mM glucose while it was increased in NWJMSCs at the same concentration and vice-versa. Both groups of cells exhibited similar behavior in the release of antioxidant enzymes, i.e., GSH reduced in both cell types at 25mM glucose while no difference was observed in catalase activity. Conclusion: Growth of DWJMSCs is enhanced at...
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