Posted by admin on Aug 1, 2018 in |
Transdermal drug delivery has been accepted as a potential non-invasive route of drug administration, with advantages of prolonged therapeutic action, less side effect, easy use, and improved patient compliance. Glimepiride is an anti-diabetic drug with a shorter half-life of ~ 5 h, low bioavailability, and extensive first-pass metabolism due to these limitations required to maintain the therapeutic level it has chosen as a transdermal drug delivery system. The present study was to formulate and evaluate the transdermal drug delivery system of Glimepiride using polymers such as tristearin, soya lecithin & Eudragit RS100 by solvent casting technique. Central composite design (CCD) was applied by using design-expert to optimize the composition of tristearin and soya lecithin for transdermal drug delivery. The prepared formulations were evaluated for different physicochemical characteristics like weight variation, folding endurance, flatness, pH of patches, % moisture content, % moisture uptake, % elongation, % drug content and % drug...
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Posted by admin on Aug 1, 2018 in |
Background and Aim: Diabetes mellitus is a disorder characterized by the body’s inability to produce insulin, leading to an increased level of blood glucose and manifestation into various complications. Diet can be considered an important factor in the prevention or management of diabetes. Spices, apart from their culinary and remedial uses, have been exploited for their pharmacological and physiological activity, e.g., clove. Our study aims to investigate the in-vitro α-glucosidase inhibitory activity of Syzygium aromaticum and its herb-drug interaction with Acarbose and Metformin. Materials and Methods: The α-glucosidase inhibitory activity was measured by glucose oxidase (GOD) method. The clove extract was subjected to phytochemical analysis. The clove extract was microencapsulated in β-cyclodextrin. The release efficiency of the microencapsulated extract was investigated and compared against microencapsulated extract and drugs (Acarbose and Metformin). Results: IC50 value of hydrocodone extract of clove was 154.36 µg/ml while that of microencapsulated spice extract was 89.414 µg/ml, proving that encapsulation of clove in β-cyclodextrin enhances α-glucosidase inhibition efficiency. IC50 values for herb-drug interaction involving clove...
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Posted by admin on Jul 31, 2018 in |
The modern breeds of chicken (Gallus gallusdomesticus) is supposed to be evolved in India from Red Jungle fowl (G. gallus), whose original habitat is South and Central India, the Himalayan Terrain, Assam, Burma, Ceylon, Sumatra, and Java. Domestication of chicken is believed to have taken place between 7,000 and 10,000 years ago. A part from G. gallus scientists has identified three closely related species that might have bred with the red jungle fowl. It is concluded from this research work; It is well documented that microbial contamination in E. coli, Salmonella, S. aureus respectively and antibiotic residue contamination of chicken with pathogens is a major public health concern worldwide. Based on the Gas chromatography study, traditional chicken has very significant fatty acid profile compared to broiler...
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Posted by admin on Jul 31, 2018 in |
Plant-based or plant-derived drugs occupy 30% of the modern system of medicine. Several plants posses a variety of biologically active compounds. Among them Camellia sinensis, belonging to the family Theaceae. Green tea is one of the most ancient and popular therapeutic beverages consumed around the world. It can be prepared as a drink, which can have many systemic health effects or an “extract” can be made from the leaves to use as medicine. Green tea is reported to contain thousands of bioactive ingredients which are almost contributed by polyphenols, which play a key role in the prevention and treatment of many diseases. The aqueous and ethanolic extracts were used for their antioxidant potential was analyzed using DPPH assay and total phenolic content. The results of the present study revealed that the green extract possesses a good antioxidant property and in the antibacterial activity potential of following this extraction used well diffusion method against the microorganisms respectively E. coli and Klebsilla...
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Posted by admin on Jun 30, 2018 in |
We report a case of Stevens-Johnson syndrome (SJS) associated with the use of etodolac, sulfasalazine SR, ceftrioxime. The patient medical history shows that she is a known case of rheumatoid. She has no improvement of joint pain and developed a few fluid filled lesions in the oral cavity, which ruptured spontaneously. She had a history of pain and burning sensation while swallowing and her first biopsy report showed erythema multiforme on hospital admission and was finally diagnosed as toxic epidermal necrolysis. The patient was treated with inj. Hydrocortisone 100 mg BD, inj. Tagocid 400 mg OD, T. Dolo 600 mg TID, inj. Piptaz 45 g BD. SJS and toxic epidermal necrolysis (TEN) are very rare adverse cutaneous reactions that can be associated with the use of Sulfasalazine. The most severe cases can result in death, and for the others, permanent skin, mucosal or ocular sequelae, which can impair the quality of life in patients. Clinicians and patients need to be aware of the signs and symptoms that often precede...
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