Posted by admin on Mar 31, 2018 in |
The advancements of cancer research if put in a nutshell can be described as: “Cancer is a genetic disease.” From the past two decades, several actors for cancer are identified, their mutations are characterized, and the pathways they control are described. Intricate relations among JAK-STAT, TGF-B, MAPK, Ras, Wnt, Notch, and Hedgehog signaling pathway have a vital role in apoptosis, survival, proliferation, and differentiation. Dysregulation of these pathways due to driver mutations are often found involved in the growth of cancer. The purpose of this review is to enlighten the advancement in these areas of cancer, specify where there is room for research, and provide a potential base for future...
Read More
Posted by admin on Mar 31, 2018 in |
Objective: To rationalize the macroscopical and microscopical study, TLC and HPTLC fingerprinting of Ficus religiosa Linn. leaves. Methods: The crude ethanolic extract of leaves of Ficus religiosa Linn. was using the macroscopical characters powder microscopical study and Preliminary phytochemical investigation of TLC and HPTLC. Results: An attempt has been made to highlight this folk herbal medicine through present study which will assist in the identification of fresh as well as dried crude samples of leaves phytochemically, macroscopically, and microscopically. TLC and HPTLC fingerprint profiling were carried out, and the salient qualitative and quantitative parameters are reported. Conclusion: The present study will provide referential information for correct identification and help in checking adulteration in the market sample used in the preparation of various herbal medicines. The present observation will also be helpful in the macroscopical and microscopical study, TLC and HPTLC fingerprinting of Ficus religiosa Linn....
Read More
Posted by admin on Feb 28, 2018 in |
Trigonella foenum-graecum, commonly known as Fenugreek, is an annual herb belonging to family Fabaceae. It is cultivated all through the world as a semiarid crop, and its seeds are rich sources of dietary protein fiber, iron B Vitamins, and several other dietary minerals. It has many potential therapeutic applications in the health sector. It contains different kinds of bioactive compounds such as diosgenin, galactomannan, 3-hydroxy-4,5-dimethyl-2(5H) furanone (stolone), 4-hydroxy isoleucene, etc. Fenugreek is one of the most ancient plants with a bunch of medicinal uses such as anti-diabetic, antipyretic, anti-inflammatory, diuretic, antiradical, antibacterial activity, etc. Fenugreek is also known to have hypocholesterolemic, digestive stimulant action, antioxidant potency, and hepatoprotective effect. Numerous experiments have been conducted to see their effectiveness to cure diseases in different ways. This review presents the major medicinal and other beneficial uses of fenugreek discovered through the last many years of research in animal and human subjects as well as in other experimental...
Read More
Posted by admin on Feb 28, 2018 in |
The aim of the study was to determine the synergistic antimicrobial activity of a selected medicinal plant extract mixture composed of Calotropis gigantean (ElaWara, Family: Asclepiadaceae), Datura metel (Kalu Attana, Family: Solanaceae) and Ricinus communis (Erandu, Family: Euphorbiaceae) against selected gram positive and gram negative bacteria. In the study, antimicrobial activity was evaluated against two-gram positive organisms; Staphylococcus aureus (ATCC 95923) and group A Streptococcus spp. (ATCC 12384) and two gram-negative organisms; Escherichia coli (ATCC 95922) and Pseudomonas aeruginosa (ATCC 27853). Agar disc diffusion method was carried out to evaluate the antibacterial activity of the selected medicinal plant extract mixture, and the inhibition zone diameters were measured. Further, minimum inhibitory concentration (MIC) was evaluated using a broth microdilution method. The inhibition zones against S. aureus and group A Streptococcus spp. were observed. In contrast, inhibition zones were not demonstrated against selected gram-negative organisms. The MIC evaluated for S. aureus was 16 mg/mL by the broth dilution method. The results revealed that the selected medicinal plant extract mixture exerted synergistic...
Read More
Posted by admin on Jan 15, 2018 in |
Herbal drugs obtained from numerous plants/herbs were extensively utilized in the prevention or treatment of various human ailments since ancient era. Ayurveda, the Indian traditional system of medicine means “science of life and longevity.” The unbeaten heritage of this system is a treasure house of knowledge for both preventive and curative health care available to humankind. It has provided treatment of many diseases using herbs, metals, minerals and formulating them into potent dosage forms. It deals with both prevention and cures the disease of a human being most systematically. Ayurveda is one of the world’s oldest alternative systems of medicines. Herbal products are of interest to many patients and health care practitioners because 70% of the world populations rely on herbal medicines for part of their primary health care system. This research work was designed to evaluate the anti-diabetic activity of Bilwadi Churna (a polyherbal formulation) in streptozotocin-induced diabetic rats and compare with standard drug glibenclamide. In conclusion, it demonstrated that polyherbal formulations have a significant and potent anti-diabetic...
Read More