Posted by admin on May 31, 2019 in |
The purpose of the current study was to formulate nanosized bromocriptine loaded mucoadhesive bio-flexy films using biopolymer from Zea mays for improved bioavailability and therapeutic efficacy via oro-trans labio mucosal route. Bromocriptine was nanosized by a novel method using 1,2,3-propanetriol as nanosizant. The biopolymer was isolated from Zea mays by treating the aqueous extract with an optimized quantity of non-aqueous solvent. Ten nanosized drug loaded films in different ratios (1:1, 1:2,1:3, 1:4 and 1:5) of biopolymer from Zea mays and Guar gum were prepared by “Solvent Casting Technique.” Biopolymer from Zea mays and Guar gum was used as film former, 1,2,3-Propanetriol and D-glucose as flexicizer. All the films were evaluated using thickness, surface pH, folding endurance, weight and content uniformity, mucoadhesive, in-vitro drug release profile, etc. The isolated biopolymer was off-white in color, biodegradable and biocompatible. All films were thin, smooth, transparent to translucent in appearance and flexible in nature. All formulations adhered to the mucosal surface for more than 24 h. The amount of film former influenced the...
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Posted by admin on Apr 30, 2019 in |
Sida cordifolia is locally known as Bala is one of those precious medicinal herbs of Malvaceae that are still included in un-utilized herbs in spite of the variety of useful pharmacological properties it possesses. Sida cordifolia have anti-inflammatory, anti-ulcer, anti-diabetic, nephroprotective, cytotoxicity, anti-hypercholesterolemia, hepatoprotective, analgesic, anti-stress and adaptogenic activity, cardiovascular, anticancer, antibacterial, antimelanogenesis, anticandidal activity, anti-parkinson’s disease, CNS depressant, fat loss, hypotensive, ultrastructure and antioxidant properties. Here, we have reviewed all the reported pharmacological properties and phytoconstituents of this valuable herb to highlight the effectiveness and potentials of this...
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Posted by admin on Apr 30, 2019 in |
Mikania cordata which belongs to the family Asteraceae is a medicinal plant that has been widely distributed through Southeast Asia and Eastern Africa. It possesses various therapeutic properties which include – anti-inflammatory, anti-ulcer, bronco-dilating, analgesic, antibiotic, anti-diarrheal, hepatoprotective, epidermal or skin protective, coagulative, anticarcinogenic, CNS depressant, anti-stress, cytotoxic, insect and scorpion bites and so on. As per from our study, there is no other review paper available till now regarding the pharmacological properties of this plant. Therefore, our paper is the first one to report a review on Mikania cordata. In this paper, along with the pharmacological properties, the other necessary features regarding the plant can be well acknowledged and can be utilized for further research and study...
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Posted by admin on Mar 31, 2019 in |
The buccal cavity is considering as a door for the digestive system. It is composed of teeth, tongue, and palate. When the food enters the buccal cavity, it is moved along the pharynx and esophagus and then go onward through the stomach, small intestine, large intestine, and anal opening. When the drug is taken by the buccal delivery system, it decreases the time needed for the drug to give its action, progresses the therapeutic action of the drug and gives a better enzymatic flora for drug absorption. It provides direct entry of drug into the systemic circulation; therefore, decrease all the drawbacks of the per-oral administration of drugs as hepatic first-pass effect, pre-systemic elimination of GIT by enzymatic degradation; between different routes of drug delivery, wafers are considered the most advantageous dosage form that taken orally and gives response at once with little side effects. The buccal region is one of the most convenient and easily approachable routes for administration of the therapeutic agents to be used locally and...
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Posted by admin on Mar 31, 2019 in |
In marine habitats, a wide diversity of microorganisms such as bacteria, archaea, fungi, and microalgae will exist. Many investigations were reported in the literature on the diversity of marine bacteria and archaea, including their role, usefulness in various domains. It is found from the literature that less work has been reported in the literature related to the role and significance of microbes. Several orders of magnitude between the number of cells will be seen in seawater samples by direct observation and the number of colonies that can grow on agar plates. To prepare subculture, colonies were inoculated in nutrient agar and broth. Bacterial communities are composed of known species which are capable of forming colonies on agar plates but do so with low efficiency. Biochemical investigations were carried out in unknown bacterial samples collected from seawater to know the characteristic of...
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