Posted by admin on Feb 28, 2019 in |
Nanoemulsions have attracted great attention in research, dosage form design, and pharmacotherapy. This is as a result of some attributes peculiar to nanoemulsions such as optical clarity, ease of preparation, thermodynamic stability and increased surface area. Poor water solubility remains the main culprit for the formulation scientist which can be overcome by canonization. Nanoemulsion is a kinetically stable and isotropic system of two immiscible liquids in the submicron size range. Nanoemulsions are composed of oil droplets dispersed in an aqueous medium and stabilized by surfactant molecules. Many parenteral nutrition and drug emulsions on the market confirm the safe use of NE over the years. Parenteral emulsions loaded with APIs (active pharmaceutical ingredients) are considered as drug delivery systems (DDS). DDS focuses on the regulation of the in-vivo dynamics, such as absorption, distribution, metabolism, and extended bioavailability, thereby improving the effectiveness and the safety of the drugs. Nanoemulsion is the thermodynamically stable isotropic system in which two immiscible liquid (water and oil) are mixed to form a single phase using...
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Posted by admin on Jan 31, 2019 in |
Commelina diffusa is widely known as the climbing dayflower or spreading dayflower, which is an annual herb belonging to the family Commelinaceae that has been used as a medicinal plant for centuries. This plant distributes dispersedly with heavy branches and slowly grows along the soil. The plant can be found in the tropical and subtropical locations worldwide. Commelina diffusa has been used for many years to heal swelling, treatment of urinary tract infection and respiratory tract infections, diarrhea, enteritis, and hemorrhoids. The plant has also been used in fever, malaria, insect, bug bites, rheumatoid arthritis, gonorrhea, influenza, and bladder infection, etc. There are some experiments that have been conducted to observe the pharmacological properties of this plant. In this paper, all the reported pharmacological properties of this plant were reviewed such as anti-inflammatory activity, antioxidant activity, antibacterial activity, antifungal activity, nephroprotective activity, hepatoprotective activity, central nervous system (CNS) depressant activity,...
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Posted by admin on Jan 31, 2019 in |
A new era of science and technology has evolved in pharmaceutical research focused on the development of different novel drug delivery systems. The evolution of an existing drug from its traditional form to a novel delivery system may considerably improve its performance in aspects of efficacy, safety, and patient compliance. The goal of any drug delivery system is to provide a therapeutic amount of drug to the proper site in the body and then maintain the desired drug concentration. The microsphere is typically injected, but oral dosage forms are being developed to improve the treatment of gastrointestinal conditions. In future microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, genetic materials, targeted and effective drug delivery. Microspheres are multiparticulate drug delivery systems which are prepared to obtain prolonged or controlled drug delivery to improve bioavailability, stability and to target the drug to a specific site at a predetermined rate. These delivery systems offer numerous advantages compared to conventional dosage forms, which include...
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