Posted by admin on Aug 1, 2016 in |
The bitter plant Andrographis paniculata has been selected to evaluate the anti haemolytic activity, antibacterial activity, and various phytochemicals present in the methanolic leaf extract. The leaf extract of Andrographis paniculata shown to have significant anti-haemolytic activity. The extract showed anti-haemolytic activity in the range from 42% to 80%. At varying concentration of plant extracts 20, 40, 60, 80 and 100 mg/ml the percent of inhibition of haemolysis recorded were 42%, 56%, 62%, 70%, 80% respectively. The methanolic leaf extract of Andrographis paniculata showed significant inhibitory effect on all of the five bacterial species such as Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Streptococcus mutans. The inhibition zones for S. aureus were 12 mm, 14 mm and 19 mm (including well 4 mm) at concentrations of 15 µl, 20 µl, and 25 µl respectively. The inhibition zones P. aeruginosa were 11 mm, 13 mm and 20 mm, 8 mm, 10 mm and 15 mm for Streptococcus mutans. The zones for E. coli were 15 mm, 16 mm...
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Posted by admin on Jun 13, 2015 in |
Number of thermal power plants in Singrauli MP (India) has changes air composition, water quality and environmental conditions that consequently affected biodiversity, wildlife and migration of livings in the region. Operational thermal power plants produce enormous quantity of pollutants mostly fly ash as a by product of combustion of coal or any pulverized fuel at higher temperature. Industrial effluents contain several heavy metals distrusted the metabolic process of living organism due to easily dispersion and mobilization in environment. The eatables and applicable potential plants and vegetables altered by these heavy metals and concern derivatives which directly and indirectly posing severe risks to human health which, extremely toxic even in low concentration, and will accumulated in organisms and ecosystems. The National Action Plan on Climate Change must tackle properly the subject of power generation, renewable energy and energy competence sources. Increasing public attentiveness is one of the most important ways to conserve biodiversity. This can be accomplished through educational programs, incentive programs, and volunteer monitoring programs. Various organizations NGO’s and...
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Posted by admin on Jun 13, 2015 in |
A reverse phase isocratic HPLC was developed and validated for the determination of levamisole in pure and tablet dosage forms. Method development was carried out on YMC C18 isocratic column, (250 mm × 4.6 mm i.d., particle size 5 μm, maintained at ambient temperature), Shimadzu LC–sol 2010 Prominence Liquid Chromatography. The mobile phase was a mixture of Acetonitrile: methanol 50:50 v/v and the flow rate was set at 1.3 ml/min and UV detection at 236 nm. Validation parameters were evaluated for the method according to the ICH guidelines. In the linearity study, linearity was observed from 2-10 μg/ml with a correlation coefficient of 0.9999 and regression coefficient of 0.999. The limit of detection and limit of quantitation for the method were 0.0209μg/ml and 0.069μg/ml, respectively. The statistical analysis shows that the method was found to be accurate, reliable, simple, and reproducible. The intra and interassay precisions were satisfactory; the values of relative standard deviations did not exceed 2%. The accuracy of the method was proved; the recovery of levamisole...
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Posted by admin on Jun 13, 2015 in |
The aim of the present research work is to design and evaluate controlled release transdermal patches of selected cardiovascular drug Atenolol. To optimize the prepared formulations by different trial approaches. To design and formulate transdermal patch of Atenolol by mercury substrate method using a few selected polymers viz., HPMC, PVP, EVA, Eudragit RS and RL100 in various proportions and Di-n-butyl Phthalate for the release retardant controlled release transdermal patch. Atenolol was chosen as a model drug for study since it possesses near ideal characteristic that a drug must have in formulating a drug delivery system such as low molecular weight, high lipid solubility, effective in low plasma concentration. It also means multiple administrations with subsequent lack of patient...
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Posted by admin on Jun 13, 2015 in |
Fluoroquinolones are synthetic fluorinated derivatives of nalidixic acid and are an important group of antibacterials along with the beta-lactam and macrolides are used for the treatment of various infectious diseases in adults; however, their use in children has been limited as the result of fluoroquinolone-induced musculoskeletal toxicity in animal studies. Those antibiotics are useful in the treatment of cystic fibrosis, urinary tract infections, neutropenia, gastrointestinal infections, meningitis with resistant bacteria, chronic suppurative otitis media, some cases of complicated acute otitis media, conjunctivitis, infections caused by Enterobacteriaceae (including the neonatal period), some mycobacterial infections, prophylaxis of anthrax and sepsis caused by other antibiotic-resistant organisms in pediatrics. Most of the available human studies showed the incidence of a musculoskeletal adverse event is relatively higher in fluoroquinolones than nonfluoroquinolone antibiotics; however, almost all AEs are reversible and transient. Hence, fluoroquinolones can be clinically considered in children when the benefit outweighs the possible...
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