Posted by admin on Jun 30, 2019 in |
Bryophyllum pinnatum (Lam.) Kurz. widely used in traditional as well as folk medicinal systems are locally known as Panphuti. Traditionally, it is used for the treatment of kidney stones, urinary tract infection, burns, and diarrhea. In the present study, pharmacognostic studies of root, stem, and leaf of B. pinnatum (Lam.) Kurz. For standardization of plant material morphological and anatomical characterization was carried out. Intra-stelar and extra-stelar secondary growth with wood and periderm formation along with deposition of starch grains were observed in the pith region of the root and cortical region of the stem. Calcium oxalate crystals were also present in the cortical region of the stem. Leaf lamina showed spongy parenchyma in mesophyll region and anisocytic type of stomata. Anthocyanin pigment was present below epidermal cells in the petiole. He results of the study could be useful in setting some diagnostic indices for the identification and preparation of monograph of the...
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Posted by admin on Jun 30, 2019 in |
Nanosuspensions have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages. Recently, nanoscale systems have received much interest as a way to resolve solubility issues because of their cost-effectiveness and technical simplicity compared to liposomes and other colloidal drug carriers. Nanosuspensions have proven to be a better alternative over other approaches currently available for improving the bioavailability of several drugs with low solubility. A formulation as nanosuspension is an attractive and promising alternative to solve these problems. Nanosuspension consists of the pure poorly water-soluble drug without any matrix material suspended in dispersion. Preparation of nanosuspension is simple and applicable to all drugs, which are water insoluble. A nanosuspension not only solves the problems of poor solubility and bioavailability but also alters the pharmacokinetics of the drug and thus improves drug safety and efficacy. Nanosuspensions have been extensively developed for a wide range of drugs and have been evaluated for in-vitro and in-vivo applications by various routes: parenteral, oral,...
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Posted by admin on Jun 30, 2018 in |
We report a case of Stevens-Johnson syndrome (SJS) associated with the use of etodolac, sulfasalazine SR, ceftrioxime. The patient medical history shows that she is a known case of rheumatoid. She has no improvement of joint pain and developed a few fluid filled lesions in the oral cavity, which ruptured spontaneously. She had a history of pain and burning sensation while swallowing and her first biopsy report showed erythema multiforme on hospital admission and was finally diagnosed as toxic epidermal necrolysis. The patient was treated with inj. Hydrocortisone 100 mg BD, inj. Tagocid 400 mg OD, T. Dolo 600 mg TID, inj. Piptaz 45 g BD. SJS and toxic epidermal necrolysis (TEN) are very rare adverse cutaneous reactions that can be associated with the use of Sulfasalazine. The most severe cases can result in death, and for the others, permanent skin, mucosal or ocular sequelae, which can impair the quality of life in patients. Clinicians and patients need to be aware of the signs and symptoms that often precede...
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Posted by admin on Jun 30, 2018 in |
Most of the existing anticancer drugs are very potent small molecules; their efficacy is constrained by their systemic toxicity, narrow therapeutic window, low drug loading, size control, scale up, cost of formulation but also as a result of drug resistance and limited cellular entry. Due to these obstacles, controlled and targeting or localized release technology has been replacing the systemic administration and has shown lots of potential for cancer treatment. Liposomes can be used to provide a sustained release of drugs, which require a prolonged plasma concentration at therapeutic levels to achieve the optimum therapeutic efficacy. In the present work, we formulate liposome containing the anticancer drug ‘6 Mercaptopurine’ for sustained delivery. The drug incorporation was carried out using the ether injection method. The cumulative drug release for the formulations, prepared by ether injection method, F1, F2, F3, F4, F5, and F6 were found to be 66.33%, 63.5%, 68.78%, 62.62%, 63.8%, and 61.25% respectively. The drug release kinetics studies suggest that in the formulations prepared by ether injection method,...
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Posted by admin on Oct 16, 2017 in |
Contaminated injection equipment have a pivotal role in the spread of HCV infection. IV drug users are one of the populations with a high risk of HCV infection. Objectives: our goal was to evaluate the role of a hazardous action (intravenous injection with contaminated equipment) in threat of public health. In this study, we collected data on 37 psychiatric patients with a history of IV drug abuse and addiction with HCV and compared to psychiatric patients with a history of IV drug abuse without HCV. Here was measured biochemical and hematological parameters and analyzed by SPSS. We found levels of AST and ALT significantly increased, but ALP and albumin none significantly decreased in patients (p≤0.05). Moreover, PT, aPTT, and ESR levels in patients were slightly higher than the control group. Also, a significant correlation between AST and ALT to serum creatinine in patients may indicate a relationship between kidney problems followed by hepatic damage. The mean value of FBS, Tg, and cholesterol levels was nearly similar in both groups....
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