Posted by admin on Jun 13, 2015 in |
The aim of the present research work is to design and evaluate controlled release transdermal patches of selected cardiovascular drug Atenolol. To optimize the prepared formulations by different trial approaches. To design and formulate transdermal patch of Atenolol by mercury substrate method using a few selected polymers viz., HPMC, PVP, EVA, Eudragit RS and RL100 in various proportions and Di-n-butyl Phthalate for the release retardant controlled release transdermal patch. Atenolol was chosen as a model drug for study since it possesses near ideal characteristic that a drug must have in formulating a drug delivery system such as low molecular weight, high lipid solubility, effective in low plasma concentration. It also means multiple administrations with subsequent lack of patient...
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Posted by admin on Jun 13, 2015 in |
Fluoroquinolones are synthetic fluorinated derivatives of nalidixic acid and are an important group of antibacterials along with the beta-lactam and macrolides are used for the treatment of various infectious diseases in adults; however, their use in children has been limited as the result of fluoroquinolone-induced musculoskeletal toxicity in animal studies. Those antibiotics are useful in the treatment of cystic fibrosis, urinary tract infections, neutropenia, gastrointestinal infections, meningitis with resistant bacteria, chronic suppurative otitis media, some cases of complicated acute otitis media, conjunctivitis, infections caused by Enterobacteriaceae (including the neonatal period), some mycobacterial infections, prophylaxis of anthrax and sepsis caused by other antibiotic-resistant organisms in pediatrics. Most of the available human studies showed the incidence of a musculoskeletal adverse event is relatively higher in fluoroquinolones than nonfluoroquinolone antibiotics; however, almost all AEs are reversible and transient. Hence, fluoroquinolones can be clinically considered in children when the benefit outweighs the possible...
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Posted by admin on Jun 13, 2015 in |
Background: The use of long-acting and permanent contraceptive methods (LAPMs) has not kept step with that of short-acting methods such as oral pills and injectables in Africa. Ethiopia is the second most populous country in sub-Saharan Africa with a high total fertility rate and high maternal and child mortality rates. Therefore, this study summarized the evidence of practice and intention to use long-acting and permanent family planning methods among women in Ethiopia using systemic review and meta-analysis. Methods and findings: Systematic review of the published literature of observational studies was conducted. Original studies were identified using databases of Medline/Pubmed and Google Scholar. Heterogeneity across studies was checked using the Cochrane Q test statistic and I2. Pool risk estimates of intention to use and practice of long-acting and permanent family planning methods were computed using a random effect model. Based on the nine observational studies included in the meta-analysis, the pooled prevalence of intention to use long-acting and permanent family planning methods among married women according to random effect DL...
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Posted by admin on Jun 13, 2015 in |
Pain is a subjective, multidimensional and unpleasant experience allied with actual or potential tissue damage comprising sensory, affective and cognitive components. Pain signals interpretation is a complex process that entails excitation of peripheral nerves and further excitation of nociceptive inputs. Painkiller is member of diverse group of drugs used to relieve pain and to achieve analgesia. Fever is recognized as physiological response which is triggered by infectious stimuli or aseptic stimuli. Elevation in body temperature occur when concentrations of prostaglandin-E2 (PGE2) increases within certain areas of the brain. These elevations alter the firing rate of neurons that control thermoregulation in the hypothalamus. It is commonly suppressed with antipyretic medications. Several traditional medicinal systems are available for the treatment of pain & fever like ayurveda, unani, chinese, homeopathic, physiotherapy & non- pharmacological procedures etc. Pain & fever treatment in allopathic system are frequently used but has many adverse effects like renal & liver dysfunction, ulceration, sedation, dizziness, nausea, vomiting, constipation, physical dependence, tolerance and respiratory depression etc. This compilation addresses...
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Posted by admin on May 2, 2015 in |
This paper deals with the concept of design and implementation of a low-cost model of an arms control moving chair using ATmega8.This moving chair can move forward, backward, left, and right. This is done with the movement (tilt) of the accelerometer, and the chair stops when there is no movement of the accelerometer. The values of the three-dimensional axis of the accelerometer can be varied and adjusted. The programming has been done through AVR compilers and burned into the ATmega8.The ATmega8 receives the information from the accelerometer and transmits it back via RX and TX pins.ATmega8 has also been interfaced to motor driver IC-L293D, wherefrom the connections go to two motors to drive the wheels of the chair. This model has been successfully implemented at a low cost, and it will benefit physically challenged persons, especially with the poor...
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