Posted by admin on Jan 31, 2019 in |
Commelina diffusa is widely known as the climbing dayflower or spreading dayflower, which is an annual herb belonging to the family Commelinaceae that has been used as a medicinal plant for centuries. This plant distributes dispersedly with heavy branches and slowly grows along the soil. The plant can be found in the tropical and subtropical locations worldwide. Commelina diffusa has been used for many years to heal swelling, treatment of urinary tract infection and respiratory tract infections, diarrhea, enteritis, and hemorrhoids. The plant has also been used in fever, malaria, insect, bug bites, rheumatoid arthritis, gonorrhea, influenza, and bladder infection, etc. There are some experiments that have been conducted to observe the pharmacological properties of this plant. In this paper, all the reported pharmacological properties of this plant were reviewed such as anti-inflammatory activity, antioxidant activity, antibacterial activity, antifungal activity, nephroprotective activity, hepatoprotective activity, central nervous system (CNS) depressant activity,...
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Posted by admin on Jan 31, 2019 in |
A new era of science and technology has evolved in pharmaceutical research focused on the development of different novel drug delivery systems. The evolution of an existing drug from its traditional form to a novel delivery system may considerably improve its performance in aspects of efficacy, safety, and patient compliance. The goal of any drug delivery system is to provide a therapeutic amount of drug to the proper site in the body and then maintain the desired drug concentration. The microsphere is typically injected, but oral dosage forms are being developed to improve the treatment of gastrointestinal conditions. In future microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, genetic materials, targeted and effective drug delivery. Microspheres are multiparticulate drug delivery systems which are prepared to obtain prolonged or controlled drug delivery to improve bioavailability, stability and to target the drug to a specific site at a predetermined rate. These delivery systems offer numerous advantages compared to conventional dosage forms, which include...
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Posted by admin on Dec 31, 2018 in |
The buccal cavity is considering as a door for the digestive system. It is composed of teeth, tongue, and palate. When the food enters the buccal cavity, it is moved along the pharynx and esophagus and then go onward through the stomach, small intestine, large intestine, and anal opening. When the drug is taken by the buccal delivery system, it decreases the time needed for the drug to give its action, progresses the therapeutic action of the drug and gives a better enzymatic flora for drug absorption. It provides direct entry of drug into the systemic circulation; therefore, decrease all the drawbacks of the per-oral administration of drugs as hepatic first-pass effect, presystemic elimination of GIT by enzymatic degradation; between different routes of drug delivery, wafers are considered the most advantageous dosage form that taken orally and gives response at once with little side effects. The buccal region is one of the most convenient and easily approachable routes for administration of the therapeutic agents to be used locally and...
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Posted by admin on Oct 31, 2018 in |
Over the last decade, the public has become increasingly aware of the potentially dangerous, systemic side effects of pain medication. Even readily available over-the-counter drugs like acetaminophen, ibuprofen, and aspirin can cause serious damage to the digestive system as a result of long term usage and/or high dosage. A possible alternative to pills for pain relief is transdermal drug delivery, the transfer of drugs across the skin. Transdermal delivery has the advantage of keeping the drug in the area where it is applied, allowing for a reduced total dose compared to a pill, but there are challenges with the method. The skin evolved as a highly efficient barrier to keep foreign substances out. After a drug gets through the skin, there is the problem of assuring drug is delivered evenly in an effective dose. Current transdermal drug delivery methods such as aspirin creams use chemical enhancers to allow the drugs to pass through the skin. The amount of aspirin that is absorbed by the body is still limited, however,...
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Posted by admin on Oct 30, 2018 in |
Dietary polyphenols, mainly phenolic acids and flavonoids, are the primary sources of antioxidants that can be generally recommended for human consumption. Polyphenols are derived from plant-based food, including fruits, vegetables, spices, herbs, etc. In the present era, there has been a great interest in the health benefits of dietary polyphenols against oxidative stress-related diseases such as diabetes mellitus, cancer, chronic kidney disease, etc. Here, the content presents an overview of dietary polyphenols in the context of relevance to human...
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